Apply AM & PM on clean skin. If you experience brief tingling or minor sloughing, don’t be concerned—this is normal:- Our 5% Retexturizing Complex gently resurfaces skin and gives cell turnover a jumpstart. As the product activates on skin, you may experience minor sloughing upon application; superficial dead skin cells are combining with the product and being lifted off to unveil smoother, brighter skin. To minimize sloughing, gently pat (don’t rub) serum into skin. Wait until skin is dry and serum is fully absorbed before applying moisturizer; if sloughing does occur, simply sweep away with fingertips. If irritation occurs, limit frequency of use and if it persists, discontinue use and consult a physician. Avoid eye area. Use sunscreen and limit sun exposure while using and the week after.