Apply AM & PM on clean skin. If you experience brief tingling or minor sloughing, don’t be concerned—this is normal:- Our 5% Retexturizing Complex gently resurfaces skin and gives cell turnover a jumpstart. As the product activates on skin, you may experience minor sloughing upon application; superficial dead skin cells are combining with the product and being lifted off to unveil smoother, brighter skin. - To minimize sloughing, gently pat (don’t rub) serum into skin. - Wait until skin is dry and serum is fully absorbed before applying moisturizer; if sloughing does occur, simply sweep away with fingertips. If irritation occurs, limit frequency of use and if it persists, discontinue use and consult a physician. Avoid eye area. Use sunscreen and limit sun exposure while using and the week after.